PROTAC SGK3 degrader-1

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [CAS 번호5017-88-83-4]

Catalog No. T13847Cas No. 2381320-35-8

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PROTAC SGK3 degrader-1

Catalog No. T13847Cas No. 2381320-35-8

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Pack Size	Price	Availability
1 mg	$479	Backorder
5 mg	$977	Backorder
25 mg	$2,280	Backorder
50 mg	$2,970	Backorder
1 mL x 10 mM (in DMSO)	$39	Backorder

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Product Introduction

Bioactivity

Description	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [CAS 번호5017-88-83-4]
In vitro	SGK3-PROTAC1 (0.3 μM) induces endogenous SGK3 degradation by 50% within 2 hours, with maximal degradation of 80% observed within 8 hours, accompanied by loss of phosphorylation of SGK3 substrate NDRG1[1].
Alias	SGK3-PROTAC1

Chemical Properties

Molecular Weight	1157.38
Formula	C₅₇H₇₃FN₁₀O₁₁S₂
Cas No.	2381320-35-8

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (69.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8640 mL	4.3201 mL	8.6402 mL	43.2010 mL
5 mM	0.1728 mL	0.8640 mL	1.7280 mL	8.6402 mL
10 mM	0.0864 mL	0.4320 mL	0.8640 mL	4.3201 mL
20 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
50 mM	0.0173 mL	0.0864 mL	0.1728 mL	0.8640 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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